Examination of continuous combination therapy with ABPC and LAPC in patients with oral and maxillofacial infections.
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- KIKUCHI KENTARO
- The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
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- NAGASHIMA HIROYUKI
- The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
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- NAKAJIMA KYOJI
- The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
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- USUI HIROYUKI
- The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
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- SASAKI HUMIHIKO
- The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
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- NAKAGAWA YOICHI
- The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
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- ASADA KOICHI
- The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
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- ISHIBASHI KATSUNORI
- The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
Bibliographic Information
- Other Title
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- 顎・口腔領域感染症におけるアンピシリン(ABPC)とレナンピシリン(LAPC)継続併用投与に関する検討
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Abstract
The Phamacokinetics of ABPC were investigated to compare the effectiveness of intravenous drip infusion of 1.0g of ABPC followed by two successive oral administrations of 0.5g of LAPC with that of three successive oral administrations of 0.5g of LAPC to outpatients with moderate to severe infections in the oral and maxillofacial regions.<BR>The results were as follows:<BR>1. In the subjects receiving drip infusion of 1.0g ABPC and two successive oral administrations of 0.5g LAPC, the concentration of ABPC reached a peak of 46.34μg/ml soon after drip infusion was stopped. Thereafter, the blood concentration was maintained over 3.8μg/ml for about 6 hours.<BR>2. When the two administration methods were compared, the blood concentration of ABPC after combination therapy was higher from the initiation of administration to 4 hours after the end of administration.<BR>3. Since blood concentrations were well maintained, this combination therapy may be effective against resistant oral streptococci, as well as other anaerobic gramnegative bacillus.
Journal
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- ORAL THERAPEUTICS AND PHARMACOLOGY
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ORAL THERAPEUTICS AND PHARMACOLOGY 18 (1), 35-39, 1999
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
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Details
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- CRID
- 1390282679707025024
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- NII Article ID
- 130004040444
- 10008944828
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- NII Book ID
- AN0023517X
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- ISSN
- 18844928
- 02881012
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed