Examination of continuous combination therapy with ABPC and LAPC in patients with oral and maxillofacial infections.

  • KIKUCHI KENTARO
    The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • NAGASHIMA HIROYUKI
    The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • NAKAJIMA KYOJI
    The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • USUI HIROYUKI
    The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • SASAKI HUMIHIKO
    The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • NAKAGAWA YOICHI
    The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • ASADA KOICHI
    The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • ISHIBASHI KATSUNORI
    The Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine

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Other Title
  • 顎・口腔領域感染症におけるアンピシリン(ABPC)とレナンピシリン(LAPC)継続併用投与に関する検討

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Abstract

The Phamacokinetics of ABPC were investigated to compare the effectiveness of intravenous drip infusion of 1.0g of ABPC followed by two successive oral administrations of 0.5g of LAPC with that of three successive oral administrations of 0.5g of LAPC to outpatients with moderate to severe infections in the oral and maxillofacial regions.<BR>The results were as follows:<BR>1. In the subjects receiving drip infusion of 1.0g ABPC and two successive oral administrations of 0.5g LAPC, the concentration of ABPC reached a peak of 46.34μg/ml soon after drip infusion was stopped. Thereafter, the blood concentration was maintained over 3.8μg/ml for about 6 hours.<BR>2. When the two administration methods were compared, the blood concentration of ABPC after combination therapy was higher from the initiation of administration to 4 hours after the end of administration.<BR>3. Since blood concentrations were well maintained, this combination therapy may be effective against resistant oral streptococci, as well as other anaerobic gramnegative bacillus.

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