Association of Single Nucleotide Polymorphisms with Periodontitis in the Japanese Population.

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  • Suzuki Asami
    Department of Periodontology, School of Dentistry, The Nippon Dental University General Dentistry, The Nippon Dental University Hospital
  • Numabe Yukihiro
    Department of Periodontology, School of Dentistry, The Nippon Dental University
  • Kamoi Kyuichi
    Department of Periodontology, School of Dentistry, The Nippon Dental University

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  • 日本人における一塩基多型と歯周炎との関連性について

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Abstract

In the time of the post sequence, attention has been increasingly focused on risk factors of 'common disease', caused by genetic and environmental factors. The oral environment and host immune response cause periodontitis and its progression, necessitating a better understanding of the genetic relationship to periodontitis. We studied relative factors of periodontitis with single nucleotide polymorphisms (SNPs) analysis. SNPs are the most common form of DNA sequence variation and their analysis covers many genes.<BR>Subjects were 13 early-onset (aggressive) periodontitis patients, 9 adult (chronic) periodontitis patients, and 19 healthy controls. We studied the association of 59 single nucleotide polymorphisms (SNPs) in candidate genes of periodontitis, such as interleukin 1 (IL 1) and tumor necrosis factor α (TNFα), with periodontitis using the TaqMan polymerase chain reactions. SNPs were selected based on linkage disequilibrium.<BR>Significant differences were seen in the frequency (p<0.05) in genotypes on cathepsin G (CTSG) and TNF receptor-associated factor 1 (TRAF 1) between early-onset periodontitis patients and controls. Significant differences were also detected in the frequency in genotypes on interleukin 10 receptor β (IL 10 RB) and matrix metalloproteinase 9 (MMP 9) between adult periodontitis patients and controls. A further significant difference was seen in the frequency in genotypes on interferon γ (IFNG) between earlyonset and adult periodontitis patients.<BR>These results suggest an association of SNPs on CTSG and TRAF 1 in early-onset periodontitis and on IL 10 RB and MMP 9 in adult periodontitis and a difference of SNPs on IFNG in early-onset and adult periodontitis.<BR>Further studies of SNPs registered in a Japanese SNPs database of JSNP, would thus clarify genetic risk factors in periodontitis. J Jpn Soc Periodontol, 44: 159-167, 2002.

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