Withdrawal of Antiepileptic Drugs in Patients with Idiopathic Generalized Epilepsy

• Kawasaki Jun

  Utano National Hospital, Kansai Regional Epilepsy Center

• Kanemoto Kousuke

  Utano National Hospital, Kansai Regional Epilepsy Center

• Shirasaka Yukiyoshi

  Utano National Hospital, Kansai Regional Epilepsy Center

• Kawai Itsuo

  Utano National Hospital, Kansai Regional Epilepsy Center

Bibliographic Information

Other Title

• 特発性全般てんかんにおける断薬の可能性について

Abstract

We studied risk factors of relapse after antiepileptic drug withdrawal in a retrospective analysis of 36 patients with idiopathic generalized epilepsy. These patients had been free of seizures for at least 2 years. Twelve patients (33%) experienced a recurrence <1 year after discontinuation or during antiepileptic drug withdrawal. Risk factors statistically related to seizure recurrence were as follows: onset in adolescence (13-18 years old) (p<0.005); >4 years duration of illness (p<0.05); >5 generalized tonic clonic seizures before control (p<0.05); juvenile myoclonic epilepsy or epilepsy with grand mal seizures on awakening (p<0.05). We conclude that these risk factors are decisive in judging whether antiepileptic drugs should be discontinued or not in patients with idiopathic generalized epilepsy.

Journal

• Journal of the Japan Epilepsy Society

  Journal of the Japan Epilepsy Society 15 (1), 1-6, 1997

  JAPAN EPILEPSY SOCIETY

Keywords

• idiopathic generalized epilepsy
• antiepileptic drug
• withdrawal
• recurrence
• risk factor

Details

• CRID: 1390001204516071936
• NII Article ID: 10008972416
• NII Book ID: AN10043823
• DOI: 10.3805/jjes.15.1
• ISSN: 13475509
• ISSN: 09120890
• Web Site: https://www.jstage.jst.go.jp/article/jjes1983/15/1/15_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997224715
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed