シラカンバ花粉症と口腔アレルギー症候群 Oral allergy syndrome in patients with birch pollen allergy

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口腔アレルギー症候群 (OAS) は, 果実や野菜が口腔粘膜と接触したことによっておこるIgEを介した即時型反応である.<BR>シラカンバ花粉症患者255名を対象にOASについて検討した.その結果1) シラカンバ花粉症患者の42.7%がOASを訴えた.2) 原因食物はリンゴ, モモ, サクランボなどが多く, 大半の症例は複数の食物が原因だった.3) OASとシラカンバ花粉症の罹病期間には有意な相関関係を認めた.4) シラカンバ花粉のCAP-RASTクラスはOAS合併群が非合併群に比べて有意に高かった.5) 診断にはプリック+プリックテストが簡便で有用であった.

Oral Allergy Syndrome (OAS) is a distinctive type of IgE-mediated allergy resulting from direct oral contact with fresh fruits and vegetable. It is proposed to be a result of cross-reacting allergens in the foods and pollens.<BR>We studied 255 patients (95 males and 160 females) with birch pollen allergy (BPA). The diagnosis was confirmed by the clinical symptoms of seasonal rhinitis and the presence of the specific antibirch IgE antibody by CAP-RAST (a class equal to or greater than 2). The onset of BPA, atopic symptoms, and a family history were examined. We asked about oral hypersensitivity to 32 kinds of fruits and vegetables such as apples, peaches, nuts, celery, and melons.<BR>The results were as follows; 1) We found that 42.7% of birch pollen allergic patients had oral symptoms after fruit and vegetable ingestion. 2) The causative foods in OAS, in order of frequency, were apples, peaches, cherries, plums, and others. A total of 82% of patients with OAS showed hypersensitivity to more than two foods. 3) The OAS was significantly related to the duration of BPA. OAS-positive patients had a longer duration of BPA than OAS-negative ones (mean years 9.50 vs 5.99; p<.000005).4) The class for specific antibirch pollen IgE levels was significantly greater in OAS-positive patients than in OAS-negative ones (p<.0000001), whereas no difference was observed in total. IgE levels between the two groups. 5) The prick+prick technique was reliable and practical without too much pseudopodia.

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  • 口腔・咽頭科 = Stomato-pharyngology

    口腔・咽頭科 = Stomato-pharyngology 13(2), 209-214, 2001-02-28

    日本口腔・咽頭科学会

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