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- 和嶋 浩一
- 慶應義塾大学医学部歯科口腔外科学教室
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- 村上 賢一郎
- 京都大学大学院医学研究科口腔機能病態学
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- 覚道 健治
- 大阪歯科大学口腔外科学第二講座
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- 小飼 英紀
- 慶應義塾大学医学部歯科口腔外科学教室
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- 田上 亜紀
- 慶應義塾大学医学部歯科口腔外科学教室 田上歯科医院
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- 藤村 和磨
- 京都大学大学院医学研究科口腔機能病態学 金沢医科大学口腔科学講座
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- 安田 真也
- 京都大学大学院医学研究科口腔機能病態学
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- 高橋 克
- 京都大学大学院医学研究科口腔機能病態学
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- 有家 巧
- 大阪歯科大学口腔外科学第二講座
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- 西村 佳也子
- 大阪歯科大学口腔外科学第二講座
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- 今村 佳樹
- 九州歯科大学歯科麻酔学講座
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- 大浦 清
- 大阪歯科大学薬理学講座
書誌事項
- タイトル別名
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- Clinical study of RAK-591 (Etodolac, Hypen<SUP>®</SUP> tablet) in treatment of temporomandibular joint disorders
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抄録
To evaluate the efficacy and safety of RAK-591 in the treatment of patients with temporomandibular joint disorders, RAK-591 was orally administered, at a dose of 200mg, twice daily, for 4 weeks. In a total of 101 subjects, the efficacy was evaluated in 86 cases, and safety in 90 cases. The improvement rate of pain on exercise (including “improved” or better) was 45.0% (36/80 cases) after 2 weeks, 50.0% (29/58 cases) after 4 weeks, and 57.0% (49/86 cases) at the end of medication (49 improved cases consisted of 16 completely improved cases at 2 weeks, and 33 improved-or-better-rated cases at 4 weeks). The pain on exercise on VAS was 51.8mm on average before administration, and 16.1mm on average at the end, showing a significant reduction (p<0.001). The maximal range of passive and pain-free opening expanded from 32.9mm, on average, before administration, to 41.4mm, on average, after 2 weeks, and 42.6mm, on average, at the end, indicating significant improvement (p<0.001). On the other hand, adverse reactions were observed in 17 of 90 cases (18.9%), but none were serious. The main adverse reactions were gastrointestinal symptoms, and these recovered after stopping the medication without any treatment.<BR>In conclusion, RAK-591 exhibited good clinical efficacy and high safety in the treatment of temporomandibular joint disorders, and it was considered to be a useful drug.
収録刊行物
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- 日本顎関節学会雑誌
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日本顎関節学会雑誌 13 (2), 248-257, 2001
一般社団法人 日本顎関節学会
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詳細情報 詳細情報について
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- CRID
- 1390282679396477184
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- NII論文ID
- 10008983709
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- NII書誌ID
- AN10093617
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- ISSN
- 18844308
- 09153004
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可