Design and Application of Ion-Channel Sensors Based on Biological and Artificial Receptors.

DOI PDF Web Site 被引用文献11件 参考文献210件
  • Sugawara Masao
    Department of Chemistry, College of Humanities and Sciences, Nihon University
  • Hirano Ayumi
    Department of Physics and Applied Physics, College of Humanities and Sciences, Nihon University
  • Bühlmann Philippe
    Department of Chemistry, University of Minnesota
  • Umezawa Yoshio
    Department of Chemistry, School of Science, The University of Tokyo

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This paper reviews approaches to chemical sensing with receptor-modified electrodes that mimic the function of natural membranes containing biological and synthetic receptor channels. We highlight different types of ion-channel sensors, focusing on the working principle and the fundamental aspects, such as sensitivity and selectivity. It is demonstrated that biological receptors such as glutamate receptor ion channels and gramicidin, embedded in bilayer lipid membranes, have the potential as sensing elements for ion channel sensors with excellent sensitivity and selectivity. In addition, higher selectivities by improved receptor desigh, taking into account the particular advantages of interfacial analyte recognition at LB membranes and SAMs, are also shown with ion-channel sensors for antibodies, protamine, heparin, abasic DNA sites, and oligonucleotides.

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