らいのぶどう膜炎とHLA-DR2対立遺伝子

• 上甲 覚

  国立療養所多磨全生園眼科

• 沼賀 二郎

  東京大学医学部眼科学教室

• 藤野 雄次郎

  東京大学医学部眼科学教室

• 増田 寛次郎

  東京大学医学部眼科学教室

• 平田 蘭子

  埼玉医科大学総合医療センター輸血部

• 前田 平生

  埼玉医科大学総合医療センター輸血部

書誌事項

タイトル別名

• HLA-DR2 alleles and uveitis inleprosy

抄録

In order to investigate the role of immunogenetic factors in the pathogenesis of uveitis in leprosy, HLA antigens were analyzed between the leprotics with and without uveitis. Sixty-five Japanese leprosy patients comprised 32 with uveitis and 33 without uveitis. Controls consisted of 138 healty subjects. A lymphocyte cytotoxicity test was used for typing HLA-A, -B, -C, -DR and -DQ antigens. HLA-DR2 genotyping was performed by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and PCR restriction fragment length polymorphism (RFLP) methods. The frequency of HLA-DR2 antigen was significantly increased in the patients with uveitis as compared with the control subjects (Pc<0.0005), whereas HLA DR53 antigen was significantly decreased (Pc<0.05). At the genomic level the frequency of HLA-DRB1*1501 was significantly increased in the patients with uveitis and without uveitis as compared with that in the controls. The association with DRB1*1501 was even stronger in patients with uveitis (odds ratio =7.1, Pc<0.000005) than in the patients without uveitis (odds ratio =4.1, Pc<0.005). Our results suggestthat HLA-DRB1 * 1501 contribute to the susceptibility to uveitis in the Japanese with leprosy.

収録刊行物

• 日本らい学会雑誌

  日本らい学会雑誌 64 (2), 112-118, 1995

  日本ハンセン病学会

キーワード

• らい
• ぶどう膜炎
• HLA抗原
• HLA-DR2対立遺伝子

詳細情報

• CRID: 1390001205095087232
• NII論文ID: 10009273513
• NII論文ID: 10010632919
• NII書誌ID: AN00198437
• DOI: 10.5025/hansen1977.64.112
• ISSN: 21851360
• ISSN: 03863980
• PubMed: 7592159
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可