生物活性海洋アルカロイドの構造と機能

• 倉本 誠

  愛媛大学機器分析センター

• 周 〓

  財団法人相模中央化学研究所

• 上村 大輔

  名古屋大学大学院理学研究科物質理学専攻化学系

書誌事項

タイトル別名

• Structures and Functions of Marine Bioactive Alkaloids.
• セイブツ カッセイ カイヨウ アルカロイド ノ コウゾウ ト キノウ

抄録

In our continuing search for bioactive substances from marine organisms, four novel alkaloids, pinnatoxins, halichlorine, pinnaic acids and norzoanthamine were isolated. The structures and functions of these marine alkaloids are described here.<BR>Pinnatoxins, potent shellfish poison, were purified form the Okinawan bivalve Pinna muricata. Pinnatoxins activate Ca²⁺ channel. Especially, toxicity of pinnatoxins B, C is as significant as that of tetrodotoxin. Halichlorine was isolated from the marine sponge Halichondria okadai. This compound inhibits the induction of VCAM-1 at IC₅₀ 7 μg/ml. Drugs that block VCAM-1 may be useful for treating coronary artery diseases, angina and noncardiovascular inflammatory diseases. Pinnaic acids, cPLA₂ inhibitor, were also obtained from the Pinna muricata. Interestingly, the structures of pinnaic acids are closely related to that of halichlorine. Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp. which suppresses the decrease in bone weight and strength in ovariectomized mice, could be a good candidate for an osteoporotic drug.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 57 (2), 105-115, 1999

  公益社団法人 有機合成化学協会

キーワード

• Marine alkaloids
• Shellfish poison
• Pinnatoxin
• VCAM-1
• Halichlorine
• cPLA<SUB>2</SUB>
• Pinnaic acid
• Osteoporosis
• Norzonathamine

詳細情報

• CRID: 1390282680254264192
• NII論文ID: 10009346697
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.57.105
• COI: 1:CAS:528:DyaK1MXht1aht7g%3D
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 4651650
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4651650
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可