人工関節素材を用いた各種粉体による炎症反応に対するインドメタシンファルネシルの効果

• 大橋 弘嗣

  大阪市立大学医学部整形外科学教室

• 島崎 朗

  大阪市立大学医学部整形外科学教室

• 山野 慶樹

  大阪市立大学医学部整形外科学教室

書誌事項

タイトル別名

• Effects of indometacin farnesil on particle induced inflammation. Using materials of joint prostheses.

抄録

In total joint replacement, particle induced inflammatory reactions cause periprosthetic bone resorption. Using an air pouch model in rats, we investigated the inflammatory reaction by alumina and polyethylene particles, and also investigated the anti-inflammatory effects of indometacin farnesil (IMF) . Irrigation fluid from the air pouch was collected and the total protein (TP) concentration and the prostaglandin E₂ (PG E₂) level were measured. To eliminate the effects of dilution, PG E₂/TP was used. The pouch tissue was histologically evaluated. Without IMF, PG E₂/TP was significantly higher by injecting alumina and polyethylene particles. In the polyethylene particles injected group, the level diminished with IMF 3 mg/kg/day, and was significantly lower with IMF 10 mg/kg/day. On the other hand, the level was not affected by IMF administration in the alumina particle injected group. A similar tendency was observed in the histology of pouch tissues. These results indicated that both alumina and polyethylene particles induced inflammatory reactions, however the anti-inflammatory effects of IMF depended on the characteristics of the particles.

収録刊行物

• 炎症

  炎症 19 (3), 151-155, 1999

  日本炎症・再生医学会

キーワード

• <I>particles</I>
• <I>indometacin farnesil</I>
• <I>polyethylene</I>
• <I>alumina</I>
• <I>air pouch model</I>

詳細情報

• CRID: 1390282679761082752
• NII論文ID: 130003856514
• NII論文ID: 10009360097
• NII書誌ID: AN00357213
• DOI: 10.2492/jsir1981.19.151
• ISSN: 18844006
• ISSN: 03894290
• Web Site: https://search.jamas.or.jp/link/ui/1999251910
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可