Endothelium-Dependent Responses in Hypertension.

• Vanhoutte Paul M.

  Institut de Recherches Internationales Servier

• Boulanger Chantal M.

  Institut de Recherches Internationales Servier

抄録

The endothelium controls the tone of the underlying vascular smooth muscle by releasing relaxing factors. These include prostacyclin, nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). In certain types of hypertension, endothelium-dependent relaxations are curtailed, because of a reduced production and/or action of endothelium-derived NO and EDHF. In the spontaneously hypertensive rat, endothelium-dependent relaxations are reduced, because of the endothelium-dependent production of vasoconstrictor prostanoids (endoperoxides and, in some cases, thromboxane A₂). These prostanoids may be produced in the vascular smooth muscle cells rather than in the endothelium. The endothelial dysfunction observed in hypertensive blood vessels is likely to be a consequence rather than a cause of the disease process. (Hypertens Res 1995; 18: 87-98)

収録刊行物

• Hypertension Research

  Hypertension Research 18 (2), 87-98, 1995

  日本高血圧学会

キーワード

• endoperoxides
• thromboxane A₂
• EDCF
• EDHF
• NO
• SHR

詳細情報

• CRID: 1390001204720513024
• NII論文ID: 10009387623
• NII論文ID: 30034931654
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.18.87
• COI: 1:CAS:528:DyaK2MXnsFaqt7o%3D
• ISSN: 13484214
• ISSN: 09169636
• ISSN: http://id.crossref.org/issn/09169636
• PubMed: 7584924
• Web Site: https://search.jamas.or.jp/link/ui/1996027667
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可