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- 氏原 久充
- 高知医科大学神経精神医学教室
書誌事項
- タイトル別名
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- Vestibular Function and Alcohol.
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Alcohol affects the oculomotor system and postural reflex, and vestibular nuclei are thought to be involved in both. In the medial vestibular nucleus (MVN), alcohol potentiates the effect of T-aminobutylic acid (GABA). Spontaneously firing MVN neurons were examined for alcohol in a brain stem slice. GABA suppressed the spikes evoked by local stimulation in the MVN neuron at the IC50 of 2 mM. One-percent alcohol potentiated the inhibitory effect of GABA, and the IC50 decreased to about 0.3 mM. Acutely dissociated MVN neurons showed similar spontaneous activity. Alcohol (0.01%) also potentiated the inhibitory effect of GABA in this preparation. The vestibular nuclei were particularly sensitive to alcohol in the brain. Therefore, the effect of alcohol is thought to be based on the potentiation of the action of GABA.
収録刊行物
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- Equilibrium Research
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Equilibrium Research 59 (3), 171-177, 2000
一般社団法人 日本めまい平衡医学会
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詳細情報
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- CRID
- 1390282679922360192
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- NII論文ID
- 10009417087
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- NII書誌ID
- AN00001485
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- ISSN
- 1882577X
- 03855716
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可