Review of the literature on Kampo-induced liver injury: In relation to problems of false-positivity on lymphocyte transformation test.

• MANTANI Naoki

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University

• KOGURE Toshiaki

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University

• KAINUMA Mosaburo

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University

• SHIMADA Yutaka

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University

• TERASAWA Katsutoshi

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University

Bibliographic Information

Other Title

• 漢方薬による肝障害報告の再検討　　リンパ球幼若化試験偽陽性の問題と関連して
• リンパ球幼若化試験偽陽性の問題と関連して

Abstract

We reexamined previous literature on Kampo-induced liver injury in Japan. These diagnoses were reviewed, independently of results on lymphocyte transformation test, by examining time to onset, course after cessation of the suspect Kampo medicine, concomitant drugs, search for non drug causes, and response to readministration. Among a total of 58 cases in the literature, 8 cases were assessed as insufficiently documented, and 4 cases were assessed as probably unrelated. Authors of the literature described that the 4 cases (probably unrelated in this study) were diagnosed with Kampo-induced liver injury based on positivity on lymphocyte transformation test. Since several experimental studies reported the mitogenic activity of Kampo medicine, lymphocyte transformation test is unsuitable as a diagnostic method of Kampo-induced liver injury. To examine the correct incidence and clinical features of Kampo-induced liver injury, reports on Kampo-induced liver injury that have been diagnosed accurately should be accumulated further.

Journal

• Kanzo

  Kanzo 43 (6), 282-287, 2002

  The Japan Society of Hepatology

Keywords

• 漢方薬
• 薬物性肝障害
• リンパ球幼若化試験
• 偽陽性

Details

• CRID: 1390001204789397632
• NII Article ID: 10009476025
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.43.282
• ISSN: 18813593
• ISSN: 04514203
• ISSN: http://id.crossref.org/issn/04514203
• Web Site: http://www.jstage.jst.go.jp/article/kanzo1960/43/6/43_6_282/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002265157
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed