鼻腔線維芽細胞からの RANTES 産生 -気道の他の部位の線維芽細胞との違い-

DOI 被引用文献1件 参考文献34件

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  • HETEROGENOUS RANTES EXPRESSION OF HUMAN AIRWAY FIBROBLASTS BY LPS FROM NOSE AND OTHER THE AIRWAYS

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Bacterial infection induces airway inflammation such as chronic sinusitis, and lipopolysaccharide (LPS) mimics bacterial infection. Airway fibroblast derived chemokines contribute to the migration and accumulation of inflammatory cells such as eosinophils in the airway. We stimulated airway fibroblasts (nasal, pharyngeal, tracheal, bronchial, lung fibroblasts) with LPS, and analysed mRNA expression and RANTES production. The expression of mRNA and the production of RANTES were detected only in nasal, but not in other airway fibroblasts, using RT-PCR and ELISA. Our data show that RANTES is inducible in nasal firoblasts by LPS, and that the responsiveness of nasal fibroblasts to LPS is distinct in the airways.<br>RANTES: Regulated And Normal T cell Expressed and presumably Secreted LPS: Lipopolysaccharide IL: Interleukin RT-PCR: reverse transcriptase-polymerase chain reaction TNF-α: tumor necrosis factor-α.

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