実験動物の肝ミクロソームにおけるアセトヘキサミド還元酵素と20β-ヒドロキシステロイド脱水素酵素活性の系統差、性差及び種差

DOI Web Site Web Site PubMed 参考文献37件

書誌事項

タイトル別名
  • Strain-, Sex- and Species-Related Differences of Acetohexamide Reductase and 20β-Hydroxysteroid Dehydrogenase Activities in Liver Microsomes of Experimental Animals
  • ジッケン ドウブツ ノ カン ミクロソーム ニ オケル アセトヘキサミド カンゲン コウソ ト 20 ベータ ヒドロキシステロイド ダツスイソ コウソ カッセイ ノ ケイトウサ セイサ オヨビ シュサ

この論文をさがす

抄録

We examined physiological and genetic factors affecting acetohexamide reductase (AHR) and 20β-hydroxysteroid dehydrogenase (20β-HSD) activities in liver microsomes of experimental animals. Pronounced strain-related differnces were found in both activities of AHR and 20β-HSD present in liver microsomes of male rats. Among rat strains tested in this study, even though a Wistar-Imamichi (WIM) rat strain was taken to lack AHR activity, it exhibited a significant 20β-HSD activity. These findings appeared to be in conflict with our conclusion reported so far, which AHR and 20β-HSD present in liver microsomes of male rats are identical enzymes. Thus the reason for this discrepancy was discussed. Furthermore, AHR and 20β-HSD activities were little or not observed in liver microsomes of female rats or male experimental animals other than the rat, indicating the existence of sex- and species-related differences in these two enzyme activities.

収録刊行物

  • 薬学雑誌

    薬学雑誌 121 (1), 85-91, 2001-01-01

    公益社団法人 日本薬学会

参考文献 (37)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ