Insulin and Cardiovascular Diseases in Japanese Work- Site Population with Borderline to Mild Hypertension

• Takishita Shuichi

  Department of Internal Medicine, University of the Ryukyus School of Medicine National Cardiovascular Center

• Abe Isao

  Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Kobayashi Kazuo

  Department of Internal Medicine, Faculty of Medicine, Kyushu University Fukuoka Red Cross Hospital

• Takata Yutaka

  Department of Internal Medicine, Faculty of Medicine, Kyushu University Kyushu Dental College

• Eto Tanenao

  Department of Internal Medicine, University of the Ryukyus School of Medicine Miyazaki Medical College, Miyazaki

• Fukiyama Koshiro

  Department of Internal Medicine, University of the Ryukyus School of Medicine

• Kojima Koh

  The Nishitesu Tsuyazaki Hospital

抄録

To clarify whether significant interrelations between hyperinsulinemia and cardiovascular diseases exist in Japanese, we analyzed serum insulin levels, fasting and after oral glucose load, in relation to blood pressure (BP), serum lipids, and incidence of acute myocardial infarction (MI) and stroke in 584 male employees of a railroad company with borderline to mild hypertension (age: 49±7 years, BP: 139± 13/90±8mmHg, body mass index: BMI 24.0±2.8, mean±SD). Those who were taking antihypertensive drugs and/or hypoglycemic agents were excluded. The subjects were classified into five groups of comparable size according to ∑IRI (area composed by insulin levels at 0, 1, 2 hours post glucose load). Although averaged age, levels of fasting glucose and HbA_1c were not significantly different among quintiles, the hyperinsulinemic groups had higher levels of fasting IRI and ∑ glucose. Multiple regression analysis revealed that ∑IRI was associated positively with BMI, ∑glucose, systolic BP, total cholesterol, and negatively with HDL-cholesterol. During 7-year follow-up 7 cases with MI and 15 cases with stroke were registered. The subjects with MI, but not with stroke were involved in higher deciles of insulin levels. These results indicate that the insulin resistance sendrome exists in Japanese middle-aged men with borderline to mild hypertension. The association with cardiovascular morbid events appeared to be evident in coronary heart disease but not in cerebrovascular disease. (Hypertens Res 1996; 19 Suppl. I:S13-S18)

収録刊行物

• Hypertension Research

  Hypertension Research 19 (SupplementI), S13-S18, 1996

  日本高血圧学会

キーワード

• insulin
• blood pressure
• myocardial infarction
• stroke
• Japanese

詳細情報

• CRID: 1390282679695791232
• NII論文ID: 10009560827
• NII論文ID: 130003456300
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.19.supplementi_s13
• ISSN: 13484214
• ISSN: 09169636
• ISSN: http://id.crossref.org/issn/09169636
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可