Relation between Coronary Blood Flow and Left Ventricular Mass in Hypertension. Noninvasive Quantification of Coronary Blood Flow by Thallium-201 Myocardial Scintigraphy.
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- Hamada Mareomi
- the Second Department of Internal Medicine, Ehime University School of Medicine
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- Kuwahara Taishi
- the Second Department of Internal Medicine, Ehime University School of Medicine
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- Shigematsu Yuji
- the Second Department of Internal Medicine, Ehime University School of Medicine
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- Kodama Koji
- the Second Department of Internal Medicine, Ehime University School of Medicine
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- Hara Yuji
- the Second Department of Internal Medicine, Ehime University School of Medicine
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- Hashida Hidetoshi
- the Second Department of Internal Medicine, Ehime University School of Medicine
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- Ikeda Shuntaro
- the Second Department of Internal Medicine, Ehime University School of Medicine
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- Ohtsuka Tomoaki
- the Second Department of Internal Medicine, Ehime University School of Medicine
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- Nakata Shigeru
- Department of Radiology, Ehime University School of Medicine
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- Hiwada Kunio
- the Second Department of Internal Medicine, Ehime University School of Medicine
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Abstract
This study was conducted to quantify coronary blood flow (CBF) noninvasively according to the fractionation principle and to elucidate the relation between CBF and left ventricular hypertrophy. CBF/cardiac output (CO), estimated on the basis of the ratio of myocardial uptake/total injected dose of thallium-201(% cardiac uptake), was determined in 14 control subjects and 40 patients with essential hypertension. CBF and CBF per 100g of myocardium (unit CBF) were calculated according to the following formulas: CBF=% cardiac uptake×CO, and unit CBF=(CBF/LVM)×100, where CO and left ventricular mass (LVM) are echocardiographically determined. There was good reproducibility of % cardiac uptake (r=0.983, p<0.0001). Percent cardiac uptake was greater in hypertensive patients (4.65±1.44%) than in control subjects (3.64±0.64%), and there was a positive correlation between % cardiac uptake and LVM. CBF (ml/min) was greater in hypertensive patients (240.7±80.5) than in control subjects (194.9±36.9), but unit CBF (ml/min/100g) was less in hypertensive patients (102.2± 26.7) than in control subjects (150.3±30.5). Multiple regression analyses showed that LVM was the most potent independent predictor of resting CBF in hypertension. Our results indicate that CBF, determined by thallium-201 myocardial scintigraphy, increases parallel to the increase in LVM, but unit CBF decreases even in the resting condition in patients with essential hypertension. (Hypertens Res 1998; 21: 227-234)
Journal
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- Hypertension Research
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Hypertension Research 21 (4), 227-234, 1998
The Japanese Society of Hypertension
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Details 詳細情報について
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- CRID
- 1390001204720446592
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- NII Article ID
- 30034931868
- 10009563564
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- NII Book ID
- AA10847079
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- COI
- 1:STN:280:DyaK1M%2FptlensA%3D%3D
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- ISSN
- 13484214
- 09169636
- http://id.crossref.org/issn/09169636
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- PubMed
- 9877515
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed