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- ARITA Mikio
- Division of Cardiology, Department of Medicine, Wakayama Medical College
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- HASHIZUME Toshikazu
- Division of Cardiology, Department of Medicine, Wakayama Medical College
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- WANAKA Yoshio
- Division of Cardiology, Department of Medicine, Wakayama Medical College
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- HANDA Satoshi
- Division of Cardiology, Department of Medicine, Wakayama Medical College
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- NAKAMURA Chigusa
- Division of Cardiology, Department of Medicine, Wakayama Medical College
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- FUJIWARA Setsuko
- Division of Cardiology, Department of Medicine, Wakayama Medical College
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- NISHIO Ichiro
- Division of Cardiology, Department of Medicine, Wakayama Medical College
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The relationship between blood pressure (BP) and cardiovascular morbidity has been appreciated for many years. Casual BP may not be repressentative of the pressure at other times. It is recognized that BP during exercise may be a more accurate predictor than casual BP. There is, however, little information about the effects of antihypertensive drugs on the BP during exercise. This study was designed to investigate the effects of various antihypertensive agents on BP during exercise. Sixty-four patients (age, 49±10 years) with untreated essential hypertension (WHO I, II) were studied during a supine ergometric exercise regimen. A graded exercise test was started at a workload of 50 W, and the load was increased by 25 W every 3 min. The hemodynamic responses to exercise were evaluated by changes in systolic and diastolic BP (SBP, DBP) and heart rate (HR). Plasma norepinephrine (NE) levels were measured at rest and during submaximal exercise, and before and after 4 weeks of treatment with metoprolol (METO), doxazosin (DOXA), trichlormethiazide (TCTZ), nifedipine (NIFE), amlodipine (AMLO) and temocapril (TEMO) between left ventricular mass index (LVMI) and BP values at rest, during exercise, and during the recovery period after exercise were assessed by multiple reguression analysis. The stepwise selection (forward conditional) method showed that LVMI was significantly associated with SBP during submaximal exercise and during the recovery period. All antihypertensive treatments decreased SBP and DBP (p<0.01) at rest. METO, AMLO and TEMO significantly lowered SBP (p<0.05) during exercise, whereas DOXA, TCTZ and NIFE induced no change in SBP. The exercise-induced increase of plasma NE was further enhanced by METO and NIFE but not by AMLO, DOXA, or TCTZ, and it was significantly suppressed by TEMO (p<0.01). There results suggest that BP during exercise is more highly associated with the progression of left ventricular hypertrophy (LVH) than is casual BP. Because antihypertensive agents differ in their effects on exercise hemodynamics, we recommend that hemodynamic factors during exercise be considered when selecting the optimal antihypertensive medication for highly active patients. (Hypertens Res 2001; 24: 671-678)
収録刊行物
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- Hypertension Research
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Hypertension Research 24 (6), 671-678, 2001
日本高血圧学会
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詳細情報 詳細情報について
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- CRID
- 1390282679697665280
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- NII論文ID
- 10009565558
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- NII書誌ID
- AA10847079
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- COI
- 1:CAS:528:DC%2BD38XjvVehuw%3D%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 11768726
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可