Effects of Vitamin E and Sesamin on Hypertension and Cerebral Thrombogenesis in Stroke-Prone Spontaneously Hypertensive Rats.

DOI PubMed 被引用文献10件 参考文献88件
  • NOGUCHI Takanori
    Graduate School of Human and Environmental Studies, Kyoto University Laboratory for Behavioral Genetics, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN)
  • IKEDA Katsumi
    Graduate School of Human and Environmental Studies, Kyoto University
  • SASAKI Yasuto
    Faculty of Nutrition, Kobe Gakuin University
  • YAMAMOTO Junichiro
    Faculty of Nutrition, Kobe Gakuin University
  • SEKI Junji
    Department of Biomedical Engineering, National Cardiovascular Center Research Institute
  • YAMAGATA Kazuo
    Graduate School of Integrated Science and Art, University of East Asia
  • NARA Yasuo
    Graduate School of Integrated Science and Art, University of East Asia
  • HARA Hiroshi
    Fujimi-Youhou-En
  • KAKUTA Hanzo
    Fujimi-Youhou-En
  • YAMORI Yukio
    Graduate School of Human and Environmental Studies, Kyoto University

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The preventive effects of sesamin, a lignan from sesame oil, and vitamin E on hypertension and thrombosis were examined using stroke-prone spontaneously hypertensive rats (SHRSP). At 5 weeks of age the animals were separated into four groups: (i) a control group; (ii) a vitamin E group, which was given a 1,000 mg α-tocopherol/kg diet; (iii) a sesamin group, given a 1,000 mg sesamin/kg diet; and (iv) a vitamin E plus sesamin group, given a 1,000 mg α-tocopherol plus 1,000 mg sesamin/kg diet for 5 weeks from 5 to 10 weeks of age. Resting blood pressure was measured by the tail-cuff method once weekly. A closed cranial window was created and platelet-rich thrombi were induced in vivo using a helium-neon laser technique. The number of laser pulses required for formation of an occlusive thrombus was used as an index of thrombotic tendency. In control rats, systolic blood pressure and the amount of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) became significantly elevated with age. However, the elevation in blood pressure and 8-OHdG were significantly suppressed in rats administrated vitamin E, sesamin, or vitamin E plus sesamin. At 10 weeks, the number of laser pulses required to induce an occlusive thrombus in arterioles of the control group was significantly lower than in the other groups (p<0.05). These results indicate that chronic ingestion of vitamin E and sesamin attenuated each of elevation in blood pressure, oxidative stress and thrombotic tendency, suggesting that these treatments might be beneficial in the prevention of hypertension and stroke. (Hypertens Res 2001; 24: 735-742)

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