Vascular Remodeling of the Carotid Artery in Patients with Untreated Essential Hypertension Increases with Age.
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- SASAKI Rie
- First Department of Internal Medicine, Nara Medical University
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- YAMANO Shigeru
- First Department of Internal Medicine, Nara Medical University
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- YAMAMOTO Yuta
- First Department of Internal Medicine, Nara Medical University
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- MINAMI Shigetoshi
- First Department of Internal Medicine, Nara Medical University
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- YAMAMOTO Junko
- First Department of Internal Medicine, Nara Medical University
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- NAKASHIMA Takao
- First Department of Internal Medicine, Nara Medical University
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- TAKAOKA Minoru
- First Department of Internal Medicine, Nara Medical University
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- HASHIMOTO Toshio
- First Department of Internal Medicine, Nara Medical University
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We examined whether hypertrophy of the carotid artery in patients with untreated essential hypertension is associated with compensatory carotid artery enlargement as these patients age. Carotid ultrasonography was evaluated in 163 patients with untreated essential hypertension (74 males and 89 females) and in 76 normotensive subjects. Intima-media end-diastolic thickness (IMT) and outer vessel diameter (VD) were measured, and relative wall thickness (IMT⁄R, R =VD⁄2) and vascular mass (VM) were calculated. Determinants of vascular hypertrophy in patients with untreated essential hypertension were also investigated. VD, VM, and IMT were significantly correlated with age in both the normotensive and hypertensive groups. Additionally, IMT was significantly correlated with VD in both groups. There was no correlation between increasing age and IMT⁄R in either group. IMT, VD and VM were significantly higher in the hypertensive group >50 years than in age-matched normotensive controls. However, IMT⁄R was significantly higher in the 50-59 years hypertensive group than in normotensive controls of the same age group. In addition to age, VM was related to systolic blood pressure, pulse pressure, fasting blood sugar, IMT, VD, and IMT⁄R in the hypertensive group. Multivariate regression analysis in the hypertensive group indicated that IMT⁄R was the strongest predictor of carotid vascular mass. Age and pulse pressure were also independently related to vascular mass. These results indicate that, as patients with untreated hypertension age, carotid arteries undergo remodeling. This should add further impetus to the implementation of appropriate hypertension treatment for such patients. (Hypertens Res 2002; 25: 373-379)
収録刊行物
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- Hypertension Research
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Hypertension Research 25 (3), 373-379, 2002
日本高血圧学会
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詳細情報
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- CRID
- 1390001204720582272
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- NII論文ID
- 10009568036
- 30002004704
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- NII書誌ID
- AA10847079
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- COI
- 1:STN:280:DC%2BD38zos1Kmtw%3D%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 12135315
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可