細胞シグナル伝達　アポトーシスの分子メカニズム

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  • Molecular mechanism of apoptosis signaling.

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Apoptosis is an unique morphologic pattern of cell death characterized by chromatin condensation and nuclear fragmentation. This programed cell death is induced by a wide variety of agents including tumor necrosis factor-α (TNF-α), Fas/Apo-1 and cytokines. However, the molecular mechanisms of the apoptotic signaling have not yet be defined. The sphingomyelin (SM) cycle, with regulated conversion of SM to ceramide by sphingomyelinase, has been extensively studied as a key pathway to induce apoptosis. On the other hand, PI 3 kinase is considered to exert a preventive action on apoptosis. We will describe the involvement of membrane lipid signaling, especially the phospholipase system in apoptosis.

収録刊行物

  • 蘇生

    蘇生 18 (1), 8-14, 1999

    日本蘇生学会

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