顎関節症患者における塩酸セフカペンピボキシル（ＣＦＰＮ‐ＰＩ，フロモックス）の血清および顎関節滑液中濃度の検討

• 兼子 隆次

  愛知県厚生連加茂病院歯科口腔外科

• 水谷 英樹

  名古屋大学医学部口腔外科学講座

• 千賀 勝広

  名古屋大学医学部口腔外科学講座

• 上田 実

  名古屋大学医学部口腔外科学講座

書誌事項

タイトル別名

• Concentration of cefcapene pivoxil hydrochloride(CFPN-PI, Flomox) in serum and in synovial fluid of temporomandibular joint with temporomandibular joint disorder.

抄録

The tissue concentration of an ester-type oral cephem antibiotic, cefcapene pivoxil hydrochloride (CFPN-PI, Flomox^®), was investigated in patients with temporomandibular joint disorder (TMD) . The results were as follows :<BR>1. The peak concentration of CFPN in serum was 17.2μg/ml after oral administration of CFPN-PI 200mg. The peak concentration in synovial fluid of temporomandibular joint (TMJ) was 0.45μg/ml. The peak level in serum was 3.8-fold that of the peak level in synovial fluid.<BR>2. The rate of transfer of CFPN from serum to synovial fluid of TMJ after oral administration was 12.1-74.0%.<BR>3. Adverse reaction was slight diarrhea in one case.<BR>Based on the above, CFPN-PI is considered to be useful for TMD patients with surgical infection.

収録刊行物

• 歯科薬物療法

  歯科薬物療法 18 (3), 134-138, 1999

  日本歯科薬物療法学会

キーワード

• 塩酸セフカペンピボキシル, フロモックス<SUP></SUP>
• 移行性
• 顎関節
• 顎関節症

詳細情報

• CRID: 1390001204728049280
• NII論文ID: 130004040457
• NII論文ID: 10009657121
• NII書誌ID: AN0023517X
• DOI: 10.11263/jsotp1982.18.134
• ISSN: 18844928
• ISSN: 02881012
• Web Site: https://search.jamas.or.jp/link/ui/2000144641
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可