成長期ラットにおける４｀Ｇ´‐β‐Ｄ‐Ｇａｌａｃｔｏｓｙｌｓｕｃｒｏｓｅ（ｌａｃｔｏｓｕｃｒｏｓｅ）の骨に及ぼす影響

• 藤田 孝輝

  株式会社横浜国際バイオ研究所

• 原 耕三

  株式会社横浜国際バイオ研究所

• 中山 秀

  マルハ株式会社中央研究所

• 西川 正純

  マルハ株式会社中央研究所

• 土屋 剛

  石巻専修大学理工学部

• 益子 詔次

  宇都宮大学教育学部

書誌事項

タイトル別名

• Effects of 4G-.BETA.-D-Galactosylsucrose(lactosucrose) on Bone in Weanling Rats.
• セイチョウキ ラット ニ オケル 4G ベータ D Galactosylsucrose lactosucrose ノ ホネ ニ オヨボス エイキョウ

抄録

Feed containing 0.7% 4^G-β-D-galactosylsucrose (lactosucrose, LS), a non-digestible oligosaccharide, was given to weanling rats aged 4 to 12 weeks to investigate the effects of LS ingestion on bone. During the test period of ingestion, the quantity of feed ingested and the amount of weight gain did not differ between the LS group and the control group. In addition, there were no abnormalities of fecal quality such as diarrhea due to administration of LS. During the period of LS ingestion, the femoral and tibial cancellous area was significantly greater in the LS group than in the control group. Tibial cancellous cartilage area after 4, 5, and 8 weeks of LS ingestion was significantly greater in the LS group than in the control group (p<0.05). During week 6 of LS ingestion, the breaking force of the femur and tibia was significantly better in the LS group than in the control group. Femoral and tibial calcium content and lumbosacral bone mineral density as measured by dual-energy X-ray densitometry (DEXA) were significantly higher in the LS group than in the control group. However, calcium metabolism-related parameters such as alkaline phosphatase (ALP), serum calcitonin, and parathyroid hormone (PTH) showed no significant changes. The above findings suggest that LS ingestion moderately stimulates osteogenesis and helps to maintain bone strength.

収録刊行物

• 日本栄養・食糧学会誌

  日本栄養・食糧学会誌 52 (6), 343-348, 1999

  公益社団法人 日本栄養・食糧学会

キーワード

• 4^G-β-D-galactosylsucrose
• rat
• cancellous area
• cancellous cartilage area
• bone strength

詳細情報

• CRID: 1390001206292556800
• NII論文ID: 10009713911
• NII書誌ID: AN00311992
• DOI: 10.4327/jsnfs.52.343
• ISSN: 18832849
• ISSN: 02873516
• ISSN: http://id.crossref.org/issn/00346659
• ISSN: http://id.crossref.org/issn/02873516
• NDL書誌ID: 4952812
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4952812
• Web Site: https://search.jamas.or.jp/link/ui/2000127142
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可