食道癌肝転移に対しての肝動注化学療法の検討

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  • INTRA-HEPATOARTERIAL CHEMOTHERAPY FOR ESOPHAGEAL CANCER PATIENTS WITH LIVER METASTASES

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Nine cases of esophageal cancer with liver metastases treated by intra-hepatoarterial chemopherapy are reported. There were non-synchronous liver metastases in 5 cases and synchronous liver metastases in 4 case. Most primary esophageaal cancers were located in the lower esophagus, and histologically were poorly differentiated squamous carcinoma or a special histological type. The depth of invasion of the primary lesions in 75% of the synchronous cases was mp. No non-synchronous cases with gastric tube ischemia or necrosis as complications of catheterization of the hepatic artery were observed. Two non-synchronous cases had ulcers on the gastric tube induced by anti-cancer agents. All of the synchronous cases required some improvisation to catheterize the hepatic artery because gastric tube reconstruction requires an intact gastroduodenal ar-tery. The intra-hepatoarterial chemotherapy regimen was 1_??_2 cycles of CDDP 20mg (4h) 5 FU 750mg (5h) 4 days and subsequent 5 FU 100mg (5h) every week or every other week. This results were: CR 13%, PR 25%, NC 38%, and PD 25%. The predominant organ metastases (lung, brain, bone) were other than liver metastases at the time of cancer death.

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