コンドロイチン硫酸プロテオグリカンとセレクチン/CD44/ケモカインの相互作用

• 川島 博人

  大阪大学大学院医学系研究科細胞分子認識分野

書誌事項

タイトル別名

• <I>Interaction of chondroitin sulfate proteoglycans with selectins, CD44, and chemokines</I>

抄録

Proteoglycans are ubiquitous components of cell surface membranes, basement membranes, and extracellular matrices in various tissues. They belong to a family of macromolecules that consist of core proteins to which glycosaminoglycans (GAGs), sulfated polysaccharides, are attached. Because of the high sulfate and carboxyl group content of their GAG moieties, proteoglycans have strong negative charges. This property allows them to interact with a wide range of proteins, including growth factors, enzymes, cytokines, chemokines, lipoproteins, and adhesion molecules. In this article, I will focus on the interaction of chondroitin sulfate proteoglycans with L-and P-selectin and CD 44, and chemokines, all of which have been implicated in leukocyte trafficking, and will provide evidence that a nonspecific electrostatic interaction is not the sole factor determining the interaction. I will also discuss biological implication of the interaction of chondroitin sulfate proteoglycans with L-and P-selectin and CD 44, and chemokines.

収録刊行物

• 炎症・再生

  炎症・再生 22 (2), 95-104, 2002

  一般社団法人 日本炎症・再生医学会

キーワード

• <I>proteoglycan</I>
• <I>glycosaminoglycan</I>
• <I>chondroitin sulfate</I>
• <I>selectin</I>
• <I>chemokine</I>

詳細情報

• CRID: 1390282680158158464
• NII論文ID: 130003708770
• NII論文ID: 10010036891
• NII書誌ID: AA11508953
• DOI: 10.2492/jsir.22.95
• ISSN: 18805795
• ISSN: 13468022
• Web Site: https://search.jamas.or.jp/link/ui/2002166230
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可