微生物膜に対するバイオサイド (5-Chloro-2-methyl-4-isothiazolin-3-one ; CMI)の抗菌活性 Antibacterial Activity of a Biocide(5-Chloro-2-methyl-4-isothiazolin-3-one ; CMI) to the Biofilm

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著者

    • 丹治 保典 TANJI Yasunori
    • 東京工業大学 大学院 生命理工学研究科 生物プロセス専攻 Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
    • 中野 肇 NAKANO Tadashi
    • 東京工業大学 大学院 生命理工学研究科 生物プロセス専攻 Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
    • 堀 克敏 [他] HORI Katsutoshi
    • 東京工業大学 大学院 生命理工学研究科 生物プロセス専攻 Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
    • 宮永 一彦 MIYANAGA Kazuhiko
    • 東京工業大学 大学院 生命理工学研究科 生物プロセス専攻 Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
    • 海野 肇 UNNO Hajime
    • 東京工業大学 大学院 生命理工学研究科 生物プロセス専攻 Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

抄録

Since 5-Chloro-2-methyl-4-isothiazolin-3-one (CMI) has relatively wide antibacterial spectrum, and low toxicity to human, it is widely used as a bactericide and fungicide, or a slime control agent for a cooling tower. The minimum inhibitory concentration of CMI to <i>E. coli</i> K-12 was 1.6mg·<i>l</i><sup>-1</sup>. Short time (-45min) exposure of <i>E. coli</i> K-12 to CMI solution of 20mg·<i>l</i><sup>-1</sup> prolonged lag phase of the cell growth. On the other hand, normal logarithmic growth phase was observed after the lag phase. When <i>E. coli</i> K-12 was exposed to CMI of 1.0mg·<i>l</i><sup>-1</sup> for 25 hours, the sterilization fraction reached to 99%. CMI concentration of more than 10mg·<i>l</i><sup>-1</sup> and more than 5 hours exposure time were needed for attaining 99.9% sterilizing fraction. The antibacterial activity of CMI to <i>E. coli</i> K-12 cells embedded in 0.6% agar was high in the upper layer of the biofilm and low in the bottom layer of the biofilm. When activated sludge was supplied with artificial sewage with CMI of 20mg·<i>l</i><sup>-1</sup>, bacteria resistant to CMI became dominant in the bacterial consortia.

収録刊行物

  • 材料と環境 : zairyo-to-kankyo

    材料と環境 : zairyo-to-kankyo 51(12), 561-565, 2002-12-15

    Japan Society of Corrosion Engineering

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各種コード

  • NII論文ID(NAID)
    10010085204
  • NII書誌ID(NCID)
    AN10235427
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    09170480
  • NDL 記事登録ID
    6509325
  • NDL 雑誌分類
    ZP41(科学技術--金属工学・鉱山工学)
  • NDL 請求記号
    Z17-266
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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