Forearm Hyperemia Is a Better Marker than Carotid Intima-Media Thickness or Ankle-Brachial Index for Coronary Artery Disease in Japanese Males under 65.
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- TONARI Satoko
- Third Department of Internal Medicine, Osaka Medical College
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- NISHIMURA Hikaru
- Third Department of Internal Medicine, Osaka Medical College
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- FUKUNISHI Kiyo
- Third Department of Internal Medicine, Osaka Medical College
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- MORI Tatsuhiko
- Third Department of Internal Medicine, Osaka Medical College
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- KITAURA Yasushi
- Third Department of Internal Medicine, Osaka Medical College
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Forearm hyperemia, carotid intima-media thickness (IMT), and ankle-brachial pressure index (ABI) are subclinical markers associated with coronary artery disease (CAD). However, it is not known which marker is most highly correlated with CAD. We therefore compared these three parameters in the same patients under 65 years of age. In 40 males with documented CAD (mean age, 53 years), we measured forearm hyperemia by plethysmography, carotid IMT by B-mode ultrasound, and ABI by Doppler ultrasonography. Microalbuminuria, serum lipids, glucose and C-reactive protein (CRP) were also measured. Thirteen normal males served as controls (mean age, 49 years). Compared with normal subjects, CAD patients had lower hyperemia (42 vs. 92%; p <0.001) and greater carotid IMT (0.81 vs. 0.67 mm; p <0.01), but ABI was similar. The sensitivity of forearm hyperemia (72%) was higher than that of carotid IMT (22%) or ABI (3%) (abnormal criteria: forearm hyperemia <60%, carotid IMT ≥1.0 mm, and ABI <0.9). The patients had higher serum low-density lipoprotein (LDL) cholesterol, glucose and CRP, and lower high-density lipoprotein (HDL) cholesterol than the controls. Albuminuria was present in 49% of patients. Subclinical markers were further analyzed by age (35-54 vs. 55-64 years). The sensitivity of carotid IMT was lower in the younger patients (4% vs. 33%), while that of forearm hyperemia (69% vs. 75%) and albuminuria (47% vs. 52%) did not change with age. While carotid ultrasound was useful in older patients (≥ 55 years), forearm hyperemia and microalbuminuria were sensitive markers irrespective of age. ABI was not useful in the Japanese men with CAD under age 65. (Hypertens Res 2003; 26: 59-65)
収録刊行物
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- Hypertension Research
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Hypertension Research 26 (1), 59-65, 2003
日本高血圧学会
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詳細情報 詳細情報について
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- CRID
- 1390001204720642304
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- NII論文ID
- 130004437010
- 10010104595
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- NII書誌ID
- AA10847079
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- COI
- 1:STN:280:DC%2BD3s7ks1WhsQ%3D%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 12661914
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可