野生シュバイカによる中枢神経系の保護作用　　培養細胞系を用いた機能性食物素材探索の試み

DOI Web Site Web Site 参考文献11件

書誌事項

タイトル別名
  • Protective Effect of Rosa duvurica Pall on Degenerative Cells from the Central Nervous System (CNS): A Trial of in vitro Identification of Functional Food Materials.
  • ヤセイ シュバイカ ニ ヨル チュウスウ シンケイケイ ノ ホゴ サヨウ バイヨウ サイボウケイ オ モチイタ キノウセイ ショクモツ ソザイ タンサク ノ ココロミ
  • A Trial of in vitro Identification of Functional Food Materials
  • 培養細胞系を用いた機能性食物素材探索の試み

この論文をさがす

抄録

Rosa duvurica pall (Rdp) is a kind of rose berries which came from the northern part of China originally. In the present paper, we examined whether or not Rdp exerts a neuronal protective action on cultured cells using the crude extracts from Rdp. When hippocampal neurons derived from a rat fetus were cultured in a serum-free medium supplemented with a reduced concentration of transferin, they began to die within a few days. Both vitamin E and K stimulated their survival at physiological concentrations of 10-8M to 10-6M. Rdp also showed similar activities like several other plants. However, none of these extracts did inhibit degeneration of glioma cells overxpressing an amyloid precursor protein (ARP), which are induced to die by chloroquine treatment and therefore regarded as one of AD degenerative model cells. Interestingly, only Rdp exerted some kind of action for repairing their damage caused by choloquine and stimulated their proliferation. It also prolonged the life of aged Chinese hamsters by about 15% on average. These data, taken together, suggest that Rdp contained some of the functional molecules that act on both neuron and glial cells from the central nervous system (CNS), probably enhancing neuronal activities in vitro and/or in vitro. Thus, this line of experiments my contribute to the promotion of the health of Japanese as well as the development of domestic agriculture in the 21' century when Japan is expected to be the most aged society.

収録刊行物

参考文献 (11)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ