デキストロメトルファンの併用によりケタミン静注療法からの覚醒が遅延した幻肢痛の１症例

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  • Delayed Awakening from Ketamine Infusion Therapy Combined with Dextromethorphan for the Treatment of Upper Limb Phantom Pain.

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NMDA receptor antagonists are effective for the treatment of neuropathic pain. We used 45mg of dextromethorphan p.o. followed by 15mg of ketamine i.v. to a 40-year-old woman with phantom pain caused by amputation of the right arm. This treatment made delayed her awakening for about 12 hours. As her phantom pain reduced during 2 days after this combined therapy, we reduced the dosage of both medicines and continued the treatment. Even 30mg of dextromethorphan p.o. combined with 1mg of ketamine i.v. put her into a dreamy state for about 8 hours. We determined that dextromethorphan increased the anesthetic effects of ketamine.

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