ジクロロ酢酸ナトリウム療法の投与量により活動性低下，肝腫大の副作用がみられたミトコンドリア病の１女児例

DOI PubMed 参考文献13件

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タイトル別名
  • Adverse Effects of Dichloroacetate in a Girl with Mitochondrial Disorder.

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We present the effects and adverse effects of dichloroacetate (DCA) in a girl with mitochondrial disorder. Oral administration of DCA 50 mg/kg per day, reduced the elevated levels of lactate to below the normal range. Treatment with DCA ameliorated electroencephalogram abnormalities, but caused the adverse effects with hepatomegaly and decreased activity, which were improved by reduction or withdrawal of DCA. The decreased activity may bean adverse effect on the central nervous system. The dosage of DCA should be adjusted for each patient.

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  • 脳と発達

    脳と発達 35 (1), 54-58, 2003

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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