肺炎球菌によるマウス呼吸器感染モデルにおける各種β‐ｌａｃｔａｍ系薬の治療効果

• 波多野 和男

  藤沢薬品工業株式会社薬理研究所

• 若井 芳美

  藤沢薬品工業株式会社薬理研究所

• 池田 文昭

  藤沢薬品工業株式会社薬理研究所

• 横田 好子

  藤沢薬品工業株式会社情報開発部

• 豊永 義清

  山梨赤十字病院小児科

書誌事項

タイトル別名

• Therapeutic effect of .BETA.-lactam antibiotics on murine streptococcal pneumonia. Relationship between MICs and therapeutic efficacies.
• Relationship between MICs and therapeutic efficacies

抄録

Therapeutic activities of several β-lactam antibiotics against murine pneumonia caused by penicillin susceptible, intermediate, and resistant strains of Streptococcus pneumoniae were examined using a murine simulation model reproducinghuman plasma concentrations. Orally active cephalosporins cefdinir (CFDN), cefcapene-pivoxil (CFPN-PI), and cefditoren-pivoxil (CDTR-PI) had potent therapeutic activity against murine pneumonia caused by penicillin-susceptible S. pneumoniae. However, these 3 orally active cephalosporins did not have enough efficacy against murine pneumonia caused by penicillin intermediate S. pneumoniae and did not have efficacy against that caused by penicillin-resistant S. pneumoniae, eventhough CFPN-PI and CDTR-PI had superior MICs against these strains compared to CFDN. Against murine pneumonia caused by penicillin-intermediate and penicillin-resistant S. pneumoniae, injectable agents panipenem/betamipron (PAPM/BP) and cefoselis (CFSL) had potent therapeutic activity with marked reduction of residualpathogen in lung tissue. Time above MIC (TAM) of the 3 orally active cephalosporins against PSSP was over 9 hours. In PISP and PRSP, CFPN-PI and CDTR-PI displayed TAM of 2 to 5 hours whilst CFDN did not show TAM. In contrast, PAPM/BP and CFSLshowed TAM of over 9 hours against all types of S. pneumoniae. These results suggest that β-lactam antibiotics with a TAM of over 9 hours have potent efficacy and a good reduction of residual pathogen in lungs, based on the relationshipbetween plasma concentration of β-lactam antibiotics and MIC, and is notdependent on the route of administration of β-lactam antibiotics. These antibiotics with enough TAM may have good potency in a clinical setting.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 50 (7), 415-421, 2002

  公益社団法人 日本化学療法学会

キーワード

• 炎球菌
• マウス
• 治療効果

詳細情報

• CRID: 1390001206287004928
• NII論文ID: 130004298122
• NII論文ID: 10010203371
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.50.415
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2003014025
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可