アレルギー症状を示す３歳未満児の血清総ＩｇＥ値と特異ＩｇＥ抗体の検討

DOI 参考文献23件

書誌事項

タイトル別名
  • TOTAL SERUM IgE LEVELS AND SPECIFIC IgE ANTIBODIES IN CHILDREN WITH ALLERGIC SYMPTOMS YOUNGER THAN 3 YEARS OLD

この論文をさがす

抄録

To clarify total serum immunoglobulin E (IgE) levels in relation to age in children with allergic symptoms younger than 3 years old and serum IgE levels that requires the measurement of specific IgE antibodies, we investigated 335 children with allergy ranging from 4 months to 2 years of age (196 boys, 139 girls). The children were divided into 3 groups; 1) the group with bronchial asthma alone, 2) the group with atopic dermatitis alone, 3) the combination group with the two diseases. Total serum IgE levels and specific IgE antibodies were measured in these children. And the same measurement were done in 55 healthy controls (21 boys, 34 girls). In addition, 20 children with atopic dermatitis alone were followed more than one year, and the same measurement were done after it.<br>(1) In children less than 1 year old, there was no significant difference in the serum IgE levels between the patients and controls. But in children of 1 year and 2 years old, there was significant difference in the serum IgE levels between children with allergy and controls. At ages of 0-2 years, there were no significant differences in the serum IgE levels between the group with atopic dermatitis alone and the group with bronchial asthma alone. But there were significant difference between the single allergic groups and the group with combined allergic diseases.<br>(2) Of children with allergy who showed serum IgE levels over the serum IgE levels of mean-1SD in the control group at each age (month) (4 to 7 months: 3IU/mL, 8 to 11 months: 8IU/mL, 1 year: 7IU/mL, 2 years: 12IU/mL), 232 children (69.2%) were RAST positive to more than one antigen. And 4 children (1.2%) showed a value below the above value.<br>From these facts, it is considered difficult to predict the presence of allergic diseases or diagnose the disease in young children with total serum IgE levels alone. In children with serum IgE levels exceeding the mean-1SD of the control group, specific IgE antibodies should be investigated.

収録刊行物

参考文献 (23)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ