高分子電解質錯体とＨＡＰ・β‐ｔｒｉｃａｌｃｉｕｍ　ｐｈｏｓｐｈａｔｅ　ｈｙｂｒｉｄ体の骨組織再構築への応用

• 齋藤 友希

  昭和大学歯学部有床義歯学教室

書誌事項

タイトル別名

• Application of Polyelectrolyte Complex and Hydroxyapatite, .BETA.-Tricalcium Phosphate Hybrid to Bone Tissue Reconstruction

抄録

Purpose: Absorption of the alveolar bone following the loss of teeth causes high absorption and reduction of the edentulous ridge hinders the recovery of stomatognathic function such as masticatory function, pronunciation and esthetics, and has a considerable influence on the maintenance and stability of the denture base after prosthesis. Therefore, control of absorption or reconstruction of alveolar bones after the loss of teeth is an important issue for the recovery of stomatognathic function. We made a hybrid body of hydroxyapatite (HAP) and β-tricalcium phosphate (β-TCP) granulation and polyelectrolyte complex (PEC)(HAP-PEC, β-TCP-PEC hybrid body) and carried out an experimental study using adult dogs in order to prevent diffusion and leakage of biomaterials by using PEC and to develop bone paste for early bone reconstruction.<BR>Methods: After making osseous defects in the mandibular bone of adult dogs, we filled the osseous defects with HAP-PEC, β-TCP-PEC hybrid bodies, and compared and examined them in two, four and six weeks, based on roentgenographic and histological findings.<BR>Results: In the roentgenographic finding, diffusion or leakage of granulation was not observed in these hybrid bodies. In the histological finding, an increase in the formation of bone regeneration in each hybrid body was observed at two, four and six weeks, compared with the control, and increase was greater. At six weeks, the osseous defects had nearly recovered to the original form. An absorption image of granulation was also observed in the β-TCP-PEC hybrid bodies in the six-week cases.<BR>Conclusions: It was suggested that the HAP-PEC, β-TCP-PEC hybrid body is extremely effective for the reconstruction of jaw bone.

収録刊行物

• 日本補綴歯科学会雑誌

  日本補綴歯科学会雑誌 47 (2), 272-281, 2003

  社団法人 日本補綴歯科学会

キーワード

• 骨充填材
• 高分子電解質錯体

詳細情報

• CRID: 1390282679389943296
• NII論文ID: 10010529301
• NII書誌ID: AN00197911
• DOI: 10.2186/jjps.47.272
• ISSN: 1883177X
• ISSN: 03895386
• Web Site: http://www.jstage.jst.go.jp/article/jjps1957/47/2/47_2_272/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004066008
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可