正常成人における運動負荷前後の鼻腔NOと鼻腔通気度•開存度の変化

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  • Changes in the Nasal NO Level, Nasal Resistance, and Nasal Patency before and after Exercise in Normal Subjects

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The nasal mucosa plays an important role in human disease resistance by repeatedly constricting and expanding.<br>The nasal membrane also shrinks after exercise and thereafter recovers gradually.<br>We sudied exercise-induced changes in nasal NO, nasal resistance, and a minimal cross-sectional area in nomal subjects and discuss the role of nasal NO.<br>Subjects were 11 healthy adults (5 men and 6 wemen 24-52 years of age). They underwent a 6-minute fixed-load treadmill exercise, walking about 6 km/hr for 6 minutes.<br>The nasal NO level, nasal resistance, and minimal cross-sectional area were measured consecutively before exercise, immediately after exercise, and at 5, 10, 15, 20, 25, and 30 minutes after exercise.<br>Nasal resistance is known to decrease immediately after exercise and thereafter gradually increases until it reaches baseline levels.<br>The minimal cross-sectional area increases immediately after exercise, but returns to baseline levels thereafter.<br>The nasal NO level decreases immediately after exercise, but does not show changes parallel to nasal resistance or minimal cross-sectional area. The nasal NO level increases gradually, but then suddenly decreases at around 20 or 25 minutes after exercise. Its level thus shows 2 dips. This pattern is caused by a depletion of the NO substrate. As a result, NO is required by the various exercise-induced changes in many parts of the body. These findings suggest that NO production is related to the maintenance of homeostasis.

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