バイオアクティブ骨セメントのインプラント体埋入時への応用

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  • Application of Bioactive Bone Cement as Substitution Material on the Treatment of Implant Surgery

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Implant therapy is an important means of improving esthetics and compensating for loss of masticatory function due to tooth defects, but it is difficult to achieve early fixation when residual bone mass is inadequate, and so bone substituties are often used. In this study we applied bioactive bone cement (CAP cement) when embedding implants into spaces experimentally created and enlarged in the mandible of dogs and assessed the possibility of its application as a bone substitute. In addition, after 8 weeks had elapsed we conducted 3-dimensional observations by a Micro-focus X-ray computed tomography device (ELE SCAN®; :μ-CT), bone density analyses, and pathohistological examinations. We also conducted a mechanical study in pig mandibles to assess mechanical strength and obtained the following results in comparison with a control group.<br/> 1. Bone density analyzed by μ-CT was 39.7% in the experimental group and 72.4% in the control group.<br/> 2. Histopathological examination<br/> 1) In the control group, penetration of epithelium along the implants was observed in the alveolar bone defect area, and examination of the bone around the implant revealed the addition of immature new osteoid tissue. There was no inflammatory reaction of the surrounding tissue.<br/> 2) In the experimental group, penetration by epithelium was not observed along the surface of the implant, and examination of the bone around the implant revealed immature new osteoid tissue between the CAP cement and the bone. The implant and the cement were joined without any intervening fibrous connective tissue.<br/> 3) Mechanical tensile strength was 344.6±69.4 N in the experimental group and 114.8±108.5 N in the control group,and the difference was statistically significant.<br/> The fact that at 8 weeks postoperatively the CAP cement had not induced an inflammatory reaction in the surrounding tissue and that it possessed mechanical strength suggests that it is a useful artificial biomaterial as a bone substitute.<br/>

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