Determination of Folate Derivatives in Rat Tissues during Folate Deficiency.

• NAKATA Rieko

  Department of Food Science and Nutrition, Nara Women's University

抄録

A method for the sensitive and specific determination of folate derivatives was developed. The method involves hydrolysis by γ-glutamyl hydrolase and high-performance liquid chromatography with electrochemical detection. The method was applied to measure the change in the level of folate derivatives in the liver, kidney, spleen and brain of rats during folate deficiency. 5, 6, 7, 8-Tetrahydrofolic acid was the major folate derivative in the liver, kidney, spleen and brain. Total concentration of folate derivatives decreased from the second week of folate deficiency in the liver, kidney, spleen and brain followed by anemia, which ap-peared at the fifth week. The level of 5, 6, 7, 8-tetrahydrofolic acid in the brain did not change during folate deficiency, but it significantly decreased in the liver, kidney and spleen.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 46 (5), 215-221, 2000

  一般財団法人 学会誌刊行センター

キーワード

• folate
• folate deficiency

詳細情報

• CRID: 1390001206320838144
• NII論文ID: 10010804460
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.46.215
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 5585052
• PubMed: 11234913
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5585052
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可