Increased Conversion Ratio of Tryptophan to Niacin by Dietary Di-n-butylphthalate.

DOI Web Site PubMed 被引用文献11件 参考文献17件
  • SHIBATA Katsumi
    Course of Food Science and Nutrition, Department of Life Studies, School of Human Cultures, The University of Shiga Prefecture
  • FUKUWATARI Tsutomu
    Course of Food Science and Nutrition, Department of Life Studies, School of Human Cultures, The University of Shiga Prefecture
  • ENOMOTO Ai
    Course of Food Science and Nutrition, Department of Life Studies, School of Human Cultures, The University of Shiga Prefecture
  • SUGIMOTO Etsuro
    Course of Food Science and Nutrition, Department of Life Studies, School of Human Cultures, The University of Shiga Prefecture

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We reported that the growth promoting activity of di-n-butylphthalate (DBP) was observed when rats were fed with a niacin-free and tryptophan-limiting diet (Shibata et al., 1982. J Nutr Sci Vitaminol 28, 173-177). The present experiment was performed to in-vestigate whether this phenomenon is attributable to the increase in the conversion ratio of tryptophan to niacin. The weaning rats were fed with a 10% (low protein diet) or 20% pro-tein (conventional protein diet) diet with or without adding 1% DBP. The conversion ratio of tryptophan to niacin was significantly higher in the DBP group than in the control group; for 10% casein diets, it increased two-fold and for 20% casein diet, about five-fold. From these results, the previous finding is possibly explained by DBP increasing the conversion ratio of tryptophan to niacin.

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