ハンセン病の病理：　心臓と血管の病理

• 矢島 幹久

  国立療養所多磨全生園研究検査科

• 成田 稔

書誌事項

タイトル別名

• Pathology of Heart and Blood Vessels in Hansen's Disease.

抄録

There are few reports on the cardiovascular changes accompanying Hansen's disease, and many aspects remain unclear.<br>We performed macroscopic and histologic examinations on the cardiovascular system in autopsy (47 cases of L type, 2 cases of B type and 14 cases of T type) and biopsy cases of Hansen's disease. The changes in small blood vessels and capillaries were also observed using electron microscopy.<br>Cardiac changes such as atrophy, hypertrophy, fibrosis and endocarditis, epicarditis and coronary sclerosis, were observed, and severe fibrosis was significantly more common in the T type cases. The heart weight tended to decrease with age in the T type cases, but such tendency was not observed in the L type cases, with somecases showing an increased heart weight.<br>Marked atrophy, fibrosis, swelling and hyperplasia were observed in the peripheral nerves around the arteries in the epicardial adipose tissue and arterioles in the myocardium. These changes were caused by ageing of the vessels feeding the peripheral nerves, together withch anges due to Hansen's disease, such as circulatory disturbance in vessels feeding the peripheral nerves, augmentation of vascular permeability and ischemic changes due to over-stratification of the basement membrance. Because these peripheral nerves were distributed around the arteries in the epicardial adipose tissue and they were probably vasomotor nerves. These results suggest that paralytic arterial changes may promote the ischemic cardiac disease or fibrosis.

収録刊行物

• 日本ハンセン病学会雑誌

  日本ハンセン病学会雑誌 66 (2), 109-118, 1997

  日本ハンセン病学会

キーワード

• ハンセン病
• 心臓
• 血管
• 病理学

詳細情報

• CRID: 1390001206322245632
• NII論文ID: 10011181990
• NII書誌ID: AN10559906
• DOI: 10.5025/hansen.66.109
• ISSN: 1884314X
• ISSN: 13423681
• PubMed: 9301210
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可