書誌事項
- タイトル別名
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- Efficacy of High-Dose Metformin in Type 2 Diabetes Mellitus
- 2ガタ トウニョウビョウ カンジャ ニ タイスル コウヨウリョウ メトホルミン ノ リンショウ コウカ ノ ケントウ
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抄録
The maximal dose of metformin is limited to 750mg/day in Japan.To evaluate the efficacy of high dose metformin, we administrated 1500mg/day for 12 weeks in 12 type-2 diabetic patients whose HbA1c exceeded 7.0% with 750mg/day. Fasting plasma glucose, HbA1c, plasma insulin, and insulin resistance index of homeostasis model assessment decreased significantly from 194±42mg/dl, 8.2±1.1%, 9.3±2.6mUml, and 4.27±1.14 to 165±28, 7.5±0.9, 7.5±3.1, and 2.95±1.36 with the increased dose. No significant change was detected in serum lactate. Although half of patients had gastrointestinal symptoms such as diarrhea, abdominal bloating, and constipation, symptoms were mild and disappeared within a week.These results indicate that high-dose metformin is effective in patients with inadequate low dose glycemic control.
収録刊行物
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- 糖尿病
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糖尿病 46 (5), 399-402, 2003
一般社団法人 日本糖尿病学会
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詳細情報 詳細情報について
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- CRID
- 1390282679881491072
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- NII論文ID
- 130004338917
- 10011239018
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- NII書誌ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL書誌ID
- 025094637
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可