圧力スイング造粒法による粉末吸入剤用顆粒の造粒の可能性ならびに薬物粒子送達性

• 湯浅 宏

  東京薬科大学薬学部製剤設計学教室

• 東 智

  東京薬科大学薬学部製剤設計学教室

• 尾関 哲也

  東京薬科大学薬学部製剤設計学教室

書誌事項

タイトル別名

• Preparation of Granules for Dry Powder Inhaler by Pressure Swing Granulation Method and Drug Particle Delivery

抄録

Pressure swing granulation is a novel fluidized bed granulation method for fine cohesive powders requiring no binders or other additives. In this study we applied the pressure swing granulation for the first time to the granulation of pharmaceutical powders. The preparation of theophylline (TP) granules by the pressure swing granulation method was attempted, and the effects of granulation conditions on the granule properties were investigated. The utility of the TP granules as dry powder inhaler (DPI) was studied. It was feasible to granulate the TP particles using no binders by the pressure swing method. The granulation process varied, depending on granulation conditions, causing a change in the hardness of granules. The amount of TP remaining in a capsule at the inhalation study of the TP granules was greatly decreased compared with the TP powder. In the granule with lower hardness, the deposition percent of TP to respirable fraction increased. These results show that it is feasible to produce the DPI granules by the pressure swing granulation method, and the utility of the DPI can be raised by using the granule of low hardness.

収録刊行物

• 薬剤学

  薬剤学 62 (2), 67-79, 2002

  公益社団法人 日本薬剤学会

キーワード

• pressure swing granulation
• dry powder inhaler
• particle design
• granule hardness
• theophylline
• drug delivery

詳細情報

• CRID: 1390001288135724928
• NII論文ID: 10011299623
• NII書誌ID: AN00266708
• DOI: 10.14843/jpstj.62.67
• ISSN: 21883149
• ISSN: 03727629
• Web Site: https://search.jamas.or.jp/link/ui/2002215098
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可