Signal Transduction Mechanism of Insulin and Insulin-Like Growth Factor-1.

DOI Web Site PubMed 被引用文献10件 参考文献47件
  • KADOWAKI TAKASHI
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • TOBE KAZUYUKI
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • HONDA-YAMAMOTO RITSUKO
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • TAMEMOTO HIROYUKI
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • KABURAGI YASUSHI
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • MOMOMURA KAORU
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • UEKI KOJIRO
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • TAKAHASHI YOSHIHIKO
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • YAMAUCHI TOSHIMASA
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • AKANUMA YASUO
    Institute for Diabetes Care and Research, Asahi Life Foundation
  • YAZAKI YOSHIO
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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抄録

Insulin and insulin-like growth factor-1(IGF-1) are two structurally related hormones which produce similar biological activities such as metabolic and growth promoting actions. Their receptors, insulin and IGF-1 receptors, also share similarities in both structure and functions such as tyrosine- specific protein kinase. We identified insulin receptor substrate-1 (IRS-1) as a common substrate for insulin and IGF-1 receptor tyrosine kinases. We generated IRS-1 knockout mice and showed that IRS-1plays a physiological role in signal transduction and biological actions of insulin and IGF-1. We also identified pp190 (IRS-2) as an alternative substrate for IRS-1.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 43 (Suppl), S33-S41, 1996

    一般社団法人 日本内分泌学会

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