書誌事項
- タイトル別名
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- Assessment of .BETA.-TCP used for the Carrier of rhBMP-2 in Rat
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Purpose: In this study, the authors histomorphologically investigated the usefulness of porous β-tricalcium phosphate (β-TCP) block with two different pore rates as a carrier of bone formation factor, recombinant human bone morphogenetic protein-2 (rhBMP-2), and bone formation.<BR>Methods: Using 10-week-old female SD rats, the parietal region was incised, and the periosteum was exfoliated to expose the parietal bone. The following four conditions were established: 1.β-TCP alone with a pore rate of 60%(60 TCP); 2. rhBMP-2 was immersed in β-TCP with a pore rate of 60%(60 TCP+BMP); 3.β-TCP alone with a pore rate of 75%(75 TCP); and 4. rhBMP-2 was immersed in β-TCP with a pore rate of 75%(75 TCP+BMP). In the 60 TCP+BMP and 75 TCP+BMP groups, 0.2 mg/cm3 β-TCP was added to rhBMP-2. The follow-up period was established at 2 and 4 weeks. After the animals were sacrificed, nondecalcified polished specimens were prepared for histomorphological investigation.<BR>Results: In the 60 TCP and 75 TCP groups, no neogenetic bone formation was detected. In the 60 TCP+BMP and 75 TCP+BMP groups, neogenetic bone formation was observed. Furthermore, β-TCP with a pore rate of 75% showed more rapid absorption.<BR>Conclusions: In the 60 TCP and 75 TCP groups, neogenetic bone formation was observed, suggesting that a complex can be prepared and that β-TCP block facilitates maintaining and gradually releasing rhBMP-2, thus β-TCP block may be a useful carrier. Therefore, treatment with β-TCP block may improve bone defects.
収録刊行物
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- 日本補綴歯科学会雑誌
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日本補綴歯科学会雑誌 47 (4), 662-670, 2003
社団法人 日本補綴歯科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204413228928
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- NII論文ID
- 10011435718
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- NII書誌ID
- AN00197911
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- ISSN
- 1883177X
- 03895386
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可