レシチン化ＳＯＤ（ＰＣ‐ＳＯＤ）のマウス体内動態に及ぼすステロイド（Ｍｅｔｈｙｌｐｒｅｄｎｉｓｏｌｏｎｅ）併用投与の影響

• 武永 美津子

  聖マリアンナ医科大学難病治療研究センター第二部門

• 五十嵐 理慧

  聖マリアンナ医科大学難病治療研究センター第二部門

• 水島 裕

  聖マリアンナ医科大学難病治療研究センター第二部門

書誌事項

タイトル別名

• Effect of Methylprednisolone on the Pharmacokinetics of Lecithinized SOD(PC-SOD) in Mice.

抄録

The effect of methylprednisolone on the pharmacokinetics of lecithinized SOD (PC-SOD) was examined in mice. Methylprednisolone was simultaneously administered with [³H] PC-SOD, however there was no significant difference in the pharmacokinetics of [³H] PC-SOD. At 24 hr, the distribution of [³H] PC-SOD in some tissues was minimally changed. These results suggest that methylprednisolone has little influence on the biodistribution of PC-SOD, and co-administration of the two shows an additive pharmacological effect in clinical study.

収録刊行物

• 臨床薬理

  臨床薬理 30 (2), 435-442, 1999

  一般社団法人 日本臨床薬理学会

キーワード

• lecithinized superoxide dismutase (PC-SOD)
• methylprednisolone
• coadministration
• pharmacokinetics

詳細情報

• CRID: 1390001205340894464
• NII論文ID: 10011537784
• NII書誌ID: AN0025404X
• DOI: 10.3999/jscpt.30.435
• ISSN: 18828272
• ISSN: 03881601
• Web Site: https://search.jamas.or.jp/link/ui/1999227518
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可