皮膚の糖脂質とその機能

• 濱中 すみ子

  理化学研究所フロンティア はまなか皮フ科クリニック

書誌事項

タイトル別名

• Epidermosides and the Relatives: Epidermis-specific Sphingolipids
• 生涯教育講座 皮膚の糖脂質とその機能
• ショウガイ キョウイク コウザ ヒフ ノ トウ シシツ ト ソノ キノウ

抄録

Keratinocytes biosynthesize glucosylceramides, acylglucosylceramides and sphingomyelins, which are potential precursors of ceramides in stratum corneum. Specificly, acylglucosylceramides are unique components comprised of both very long chain fatty acids as the amide-linked fatty acids and as esterified fatty acid linked through the ω-hydroxy group. The one found in the human epidermis consists of two acylglucosylceramide groups, one containing sphingenine and the other containing phytosphingosine with a single double bond. The linoleic acid content as ester-linked fatty acids is very high in human epidermis. We named these acylglucosylceramides contain linoleic acid “epidermosides”; they are key molecules of the epidermal permeability barrier. Epidermosides are the precursors of acylceramides and ω-hydroxy ceramides ; the latter are the major components of the corneocyte lipid envelope. Glucosylceramides and sphingomyelins have structural heterogeneities in the ceramide portion. All ceramide species are derived from glucosylceramides, while a fraction of Cer 2 and Cer 5 come from sphingomyelins.

収録刊行物

• 日本皮膚科学会雑誌

  日本皮膚科学会雑誌 112 (2), 107-115, 2002

  公益社団法人 日本皮膚科学会

キーワード

• sphingolipid
• glucosylceramide
• acylglucosylceramide
• epidermoside
• sphingomyelin
• ceramide

詳細情報

• CRID: 1390282680715348992
• NII論文ID: 10011539045
• NII書誌ID: AN00196602
• DOI: 10.14924/dermatol.112.107
• ISSN: 13468146
• ISSN: 0021499X
• NDL書誌ID: 025120448
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025120448
• Web Site: https://search.jamas.or.jp/link/ui/2002161781
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可