細胞内Tumor Necrosis Factorは生体防御因子として働く

• 渡辺 直樹

  札幌医科大学医学部附属病院検査部

書誌事項

タイトル別名

• Endogenous Tumor Necrosis Factor Acts as a Cytoprotective Factor

抄録

Endogenous tumor necrosis factor (enTNF) acts as a cross-resistant factor against the cytotoxicity caused by exogenous TNF, doxorubicin, and heat, not only via induction of manganous superoxide dismutase, but also via enhancement of the heat shock element binding activity of heat shock factor 1, followed by augmentation of HSP 72 expression. These findings suggest that prediction of the efficacy of various therapeutic modalities against cancer is possible by measurement of enTNF expression.

収録刊行物

• Japanese Journal of Clinical Chemistry

  Japanese Journal of Clinical Chemistry 28 (3), 135-145, 1999

  一般社団法人 日本臨床化学会

キーワード

• manganous superoxide dismutase (MnSOD)
• 熱ショック蛋白 (heat shock protein: HSP)
• 細胞防御

詳細情報

• CRID: 1390282679888918144
• NII論文ID: 130003357877
• NII論文ID: 10011546847
• NII書誌ID: AN00252758
• DOI: 10.14921/jscc1971b.28.3_135
• COI: 1:CAS:528:DyaK1MXmsF2ksbg%3D
• ISSN: 21874077
• ISSN: 03705633
• Web Site: https://search.jamas.or.jp/link/ui/2000034644
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可