急性低音障害型感音難聴に対する異なるステロイド剤による効果の相違について

DOI 被引用文献5件 参考文献27件

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  • The Difference of the Effect of Various Types of Steroids for Acute Low-Tone Sensorineural Hearing Loss.

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In patients with acute low-tone sensorineural hearing loss (ALHL), treatment progress was compared in 2 groups of prednisolone, tapering gradually from 60mg/day for 7 days, administrated group and dexamethasone, tapering gradually from 10mg/day for 7 days, administrated group. In the prednisolone group, there were some cases in which the hearing acuity was once recovered then deteriorated in the midpoint of treatment, and these hearing levels were significantly deteriorated compared to the levels at the same day in the dexamethasone group. An endolymphatic hydropse was considered as an etiology because there are some cases with ALHL later developed Meniere disease. It was known that the aldosterone which was mineral corticoids induced endolymphatic hydrops. The possibility of the mineral corticoid activity of prednisolone which might affect the liquid control of endolymph was considered.

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