新鮮臨床分離Ｃａｎｄｉｄａ属，Ａｓｐｅｒｇｉｌｌｕｓ属株のｍｉｃａｆｕｎｇｉｎに対する感受性

• 池田 文昭

  藤沢薬品工業株式会社

• 中井 徹

  藤沢薬品工業株式会社

• 若杉 昌宏

  藤沢薬品工業株式会社

• 堀田 久範

  藤沢薬品工業株式会社

• 樋口 貞夫

  藤沢薬品工業株式会社

• 小林 寅哲

  株式会社三菱化学ビーシーエル

書誌事項

タイトル別名

• MIC of micafungin against fresh clinical isolates of genus Candida and Aspergillus

抄録

The in vitro antifungal activity of micafungin (MCFG) against Candida and Aspergillus species, clinically isolated in Japan between October 2001 and August 2002, were compared with those of amphotericin-B, miconazole, fluconazole, itraconazole and 5-fluorocytosine using the broth microdilutionmethod, as specified by the National Committee for Clinical Laboratory Standards (NCCLS) documents M 27-A and M 38-P. The MIC₉₀ levels of MCFG for Candida albicans (including fluconazole-resistant isolates), Candida tropicalis, Candida glabrata, and other Candida spp. were 0.0625μg/mL or lower, which were lower than those for the other antifungal agents tested. The MICs of MCFG for Candida parapsilosis and Candida guilliermondii ranged from 0.025 to 1μg/mL, which were comparable to or slightly higher than those for the other antifungal agents tested. The MICs of MCFG for Aspergillus fumigatus, Aspergillus niger, Aspergillus terreus, Aspergillus flavus and other Aspergillus sp. ranged from 0.002 to 0.0313μg/mL, which were lower than those for the other antifungal agents tested. None of the isolates showed a lowered susceptibility to MCFG, as indicated by the fact that the MIC values of MCFG were distributed within 2 dilutions for each Candida species and below 0.0313μg/mL for all Aspergillus isolates.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 51 (8), 485-489, 2003

  公益社団法人 日本化学療法学会

キーワード

• キャンディン系抗真菌薬
• 薬剤感受性試験

詳細情報

• CRID: 1390282681262792576
• NII論文ID: 130004298188
• NII論文ID: 10011596875
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.51.485
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2004082769
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可