歯原性角化嚢胞の角化のタイプによる臨床病理学的相違

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  • Clinicopathological variants of the keratinization type of odontogenic keratocyst.

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We comparatively studied differences in clinicopathological features according to the keratin type of the epithelium of the cyst wall and differences in cell kinetics using antibodies against PCNA in 33 patients with odontogenic keratocysts (36 cysts). The subjects presented at the patient clinic of our department during the 17 years from 1979 to 1995 and satisfied the histopathological criteria described by Pindborg et al. When classified according to the keratin type of the cyst-wall epithelium, there were 7 (19.4%) cysts with orthokeratin (group I), 5 (13.9%) cysts with parakeratin accompanied by partial orthokeratin (group II), and 24 (66.7%) cysts with parakeratin (group III). The average age of group I was slightly younger than that of group III. The number of women was higher than that of men in group I, while men slightly outnumbered women in the group M. No cysts in group I were associated with basal cell nevus syndrome. The form of all cysts was unilocular in the group I, while in group III, cysts showed various forms, including multilocular cysts. The number of cysts with impacted teeth was higher in group III than in the other two groups. The size of some cysts was 8 cm or larger in group III, while in the group I, there were no cysts of 8 cm or larger. No significant differences were observed in the PCNA-positive rate between group I and III.

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