ウサギＶＸ２舌癌の進展に関わるＰＣＮＡの発現と腫よう血管新生の意義に関する研究

• 二宮 康郎

  福岡歯科大学口腔外科学第一講座

書誌事項

タイトル別名

• Expression of PCNA and the role of tumor angiogenesis in progression of VX2 carcinoma of the tongue in rabbits.

抄録

Angiogenesis, the induction of new capillaries and venules, is associated with tuomr growth and may promote the metastasis of tumor cells. Tumor angiogenesis in rabbits with VX 2 carcinoma of the tongue was investigated to determine relations with tumor size, metastasis, and proliferative activity. After implantation in the rabbit tongue, VX 2 carcinoma grew slowly until day 12 and then started to grow rapidly and metastasize. To estimate the proliferative activity of the tumor, the ratios of proliferating cell nuclear antigen (PCNA) were computer-generated with a CAS 200 image analysis system. The PCNA positive area was small (50.54%) on day 7 and increased significantly (73.19%) on day 12, Microvessels were immunohistologically stained with anti-CD31 antibody and counted. Microvessel density was low (29.35) on day 7 and increased significangly (70.1) on day 12. Concomitant increases in PCNA positive area and microvessel density suggest that tumor angiogenesis is related to the prolferative activity of VX 2 carcinoma of the tongue. Angiographic and vascular cast studies also suggested the presence of newly-formed microvessels in the tongue tumor. Furthermore, PCNA-positive cells in tumor nests were frequently observed near highly vascularized areas. These data suggest that tumor angiogenesis plays an important role in the progression of VX 2 carcinoma of the tongue.

収録刊行物

• 日本口腔外科学会雑誌

  日本口腔外科学会雑誌 43 (4), 268-279, 1997

  社団法人 日本口腔外科学会

キーワード

• 腫瘍血管新生
• 増殖核抗原
• VX2舌癌

詳細情報

• CRID: 1390282681505866752
• NII論文ID: 10011660493
• NII書誌ID: AN00189163
• DOI: 10.5794/jjoms.43.268
• ISSN: 21861579
• ISSN: 00215163
• Web Site: https://search.jamas.or.jp/link/ui/1997201136
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可