Effects of 17β-Estradiol and the Japanese Herbal Medicine Keishi-bukuryo-gan on the Release and Synthesis of Calcitonin Gene-Related Peptide in Ovariectomized Rats
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- Noguchi Masamichi
- Tsumura Research Institute Medical Evaluation Laboratory
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- Ikarashi Yasushi
- Tsumura Research Institute Medical Evaluation Laboratory
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- Yuzurihara Mitsutoshi
- Tsumura Research Institute Medical Evaluation Laboratory
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- Kase Yoshio
- Tsumura Research Institute Medical Evaluation Laboratory
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- Takeda Shuichi
- Tsumura Research Institute Medical Evaluation Laboratory
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- Aburada Masaki
- Tsumura Research Institute Medical Evaluation Laboratory
書誌事項
- タイトル別名
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- Effects of 17.BETA.-Estradiol and the Japanese Herbal Medicine Keishi-bukuryo-gan on the Release and Synthesis of Calcitonin Gene-Related Peptide in Ovariectomized Rats
- Effects of 17 ベータ Estradiol and the Japanese Herbal Medicine Keishi bukuryo gan on the Release and Synthesis of Calcitonin Gene Related Peptide in Ovariectomized Rats
この論文をさがす
抄録
The purpose of this study is to clarify the effects of 17β-estradiol and the Japanese herbal medicine Keishi-bukuryo-gan on the release and synthesis of calcitonin gene-related peptide (CGRP) in ovariectomized (OVX) rats. The effect of ovariectomy on the release or synthesis was evaluated by measuring CGRP concentration in plasma after capsaicin (1.0 mg/kg, i.p.) injection or by measuring CGRP concentration and its mRNA expression in dorsal root ganglia in OVX rats. Ovariectomy attenuated the capsaicin-evoked increase in plasma concentration of CGRP, which was restored by treatment with 17β-estradiol (0.010 mg/kg, s.c.) or Keishi-bukuryo-gan (1,000 mg/kg, p.o.) for 7 days after ovariectomy. However, no significant differences were observed in the CGRP concentration and the mRNA expression of dorsal root ganglia by treating the rats with ovariectomy, 17 β-estradiol, and Keishi-bukuryo-gan. These results suggest not only that estrogen deficiency attenuates CGRP release but also that 17β-estradiol or Keishi-bukuryo-gan normalizes the attenuated release process.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 93 (1), 80-86, 2003
公益社団法人 日本薬理学会
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キーワード
詳細情報
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- CRID
- 1390001205177193472
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- NII論文ID
- 10011706158
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- NII書誌ID
- AA11806667
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- COI
- 1:STN:280:DC%2BD3svktFagtg%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 6691660
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- PubMed
- 14501156
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可