ビスフェノールＡの生分解過程におけるエストロゲン様活性の変化

• 大谷 仁己

  群馬県衛生環境研究所

• 嶋田 好孝

  群馬県衛生環境研究所

• 白石 不二雄

  国立環境研究所

• 小澤 邦寿

  群馬県衛生環境研究所

書誌事項

タイトル別名

• Variation of Estrogenic Activities during the Bio-degradation of Bisphenol A
• ビスフェノール A ノ セイブンカイ カテイ ニ オケル エストロゲン ヨウ カッセイ ノ ヘンカ

抄録

Variation of estrogenic activities during the bio-degradation of bisphenol A (BPA) with isolated bacteria strain MO6 were measured using the yeast two-hybrid assay method. Accumulation of a degradation intermediate, 4, 4'-dihydroxy-α-methylstilbene (DHMS), depended on the pre-incubation conditions of degrading bacteria. Thus, maximum estrogenic activity during the bio-degradation of BPA varied with the pre-incubation conditions of degrading bacteria. In a case when a high concentration of DHMS was accumulated, estrogenic activity rose to a level corresponding to 1, 600 mg/l BPA although the initial BPA was only 30 mg/l. Even in another case when a low concentration of DHMS was accumulated, estrogenic activity rose to a level corresponding to 150 mg/l BPA, three times that of initial BPA concentration.<BR>Temporal increase in estrogenic activity was observed in only 1 of 8 samples, when BPA was degraded by a river water. In the river water, DHMS did not seem to be accumulated such a level that the contribution to the estrogenic activity was detectable.

収録刊行物

• 環境化学

  環境化学 13 (4), 1027-1031, 2003

  一般社団法人 日本環境化学会

キーワード

• bisphenol A
• bio-degradation
• estrogenic activity
• yeast two-hybrid assay
• river water

詳細情報

• CRID: 1390282679346741504
• NII論文ID: 10011893487
• NII書誌ID: AN10547099
• DOI: 10.5985/jec.13.1027
• ISSN: 18825818
• ISSN: 09172408
• NDL書誌ID: 6801563
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6801563
• Web Site: http://www.jstage.jst.go.jp/article/jec1991/13/4/13_4_1027/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可